NFL Week 1 betting predictions highlight Packers and Bengals, presenting odds, lines, picks, spreads, and 2025 forecasts

In the upcoming NFL season, there's a buzz of excitement as teams gear up for the first game day. A model that has shown impressive accuracy in its NFL predictions is shedding light on several key matchups and underdogs to watch.

Last season, Cincinnati Bengals' quarterback Joe Burrow led the league in both passing yards (4,918) and passing touchdowns (43), setting the stage for a promising season ahead. However, the spotlight isn't just on the Bengals. The model predicts a potential upset in the Bengals' match against the Cleveland Browns, with Cincinnati (-5.5, 47.5) covering the spread on the road.

Meanwhile, the Browns struggled mightily in the previous season, ranking last in third-down offense, committing the second-most turnovers, and having bottom-five rankings in both rushing offense and redzone scoring. In contrast, the Green Bay Packers, fresh off acquiring Micah Parsons, are projected to cover at home versus the Lions.

The Over (47.5) is projected to hit in over 50% of simulations for the Packers vs. Lions game. Matthew Golden, the Packers' new No. 1 wideout, is projected to lead the team in receiving in Week 1. The line for this game has moved one point in favor of Green Bay since the Parsons trade news broke.

The model has also revealed three underdogs that are predicted to outright win in Week 1 NFL games. Among them are the Denver Broncos, seen as underdogs with a 25.0% chance according to the Super Bowl odds, and the New York Jets, who are slight underdogs in their game against the Steelers.

The NFL Week 1 schedule is packed with close games, including Chiefs vs. Chargers (+3), Buccaneers vs. Falcons (+2.5), Dolphins vs. Colts (-1.5), and Steelers vs. Jets (+3). Several games have spreads over a touchdown, such as Titans vs. Broncos (7.5).

The model, which simulates every NFL game 10,000 times, has a proven track record, returning well over $7,000 since its inception. The website offers Week 1 NFL odds, lines, live spreads, and scores, providing fans with all the information they need to make informed decisions.

In addition to these predictions, the website also offers Week 1 NFL picks for every game. As the first game day approaches, keep an eye on these predictions to stay ahead of the curve.